Lipedema is a chronic and progressive fat metabolism disorder, often mistaken for a purely cosmetic issue or simple “excess weight.” It is characterized by symmetrical fat accumulation, typically in the legs and sometimes the arms, and it occurs almost exclusively in women.

Unlike typical fat deposits, lipedema is resistant to weight loss and is accompanied by pain, tenderness, and limited mobility as it progresses. It has a profound impact on both physical and emotional well-being. Fortunately, with accurate diagnosis and expert treatment, symptoms can be controlled and quality of life significantly improved.

Lipedema Explained

Lipedema is a condition caused by the abnormal and uneven growth of fat cells. It usually affects the hips, thighs, knees, and lower legs; in some cases, it can also extend to the arms. The upper body typically remains unaffected.

In individuals with lipedema:

• Fat distribution is disproportionate compared to the rest of the body
• The lower body appears much larger than the upper body
• Arms and legs thicken symmetrically
• Feet and hands are not affected — a key difference from lymphedema

Symptoms of Lipedema

Symptoms vary depending on the stage, but the most common signs include:

• Symmetrical thickening of the legs
• Pain and tenderness even with light touch
• Frequent bruising, even with minimal impact
• “Orange peel” skin texture (cellulite-like appearance)
• Fatigue, heaviness, and difficulty standing for long periods
• Resistance to weight loss in affected areas despite diet and exercise
• Palpable nodular fat deposits around the hips and thighs

Important: Lipedema is not obesity. However, it can coexist with obesity, complicating the condition further.

Stages of Lipedema

Lipedema is a progressive condition, generally classified into 3 main stages:

• Stage 1: Skin appears smooth, but nodular fat can be felt beneath the surface. Bruising and sensitivity are noticeable.
• Stage 2: Visible skin dimpling, orange peel texture, and more pronounced pain upon touch.
• Stage 3: Fat masses harden and become uneven. Legs may thicken enough to alter shape. Knee areas become prominent, and sagging may occur.
• Stage 4 (Lipo-lymphedema): Advanced lipedema with secondary lymphedema. Swelling becomes visible around the ankles. This stage is complex and difficult to manage.

Early diagnosis and treatment are critical to prevent disease progression.

Causes of Lipedema

The exact cause of lipedema is unknown, but genetic and hormonal factors are believed to play a major role. It often begins during periods of hormonal change, such as:

• Puberty
• Pregnancy
• Use of birth control pills
• Menopause

Family history is common, with 60–70% of patients reporting similar symptoms in relatives.

How Is Lipedema Diagnosed?

Lipedema is primarily diagnosed through a clinical examination by an experienced physician. The following tools may assist in the diagnosis:

• Ultrasound: To assess the thickness and structure of subcutaneous fat tissue
• Doppler Ultrasound: To rule out venous insufficiency or lymphedema
• MRI / DEXA Scan: To measure fat volume and tissue composition

A key distinguishing factor: lipedema does not cause swelling in the feet or hands — this helps differentiate it from lymphedema.

Treatment Options for Lipedema

There is currently no cure for lipedema through medication, but its progression can be slowed and symptoms can be managed. A comprehensive, multi-modal approach is typically used:

1. Compression Therapy

• Use of compression stockings (especially class 2–3 lymphatic garments)
• Improves circulation and reduces swelling
• Recommended for daily use

2. Manual Lymphatic Drainage (MLD)

• Gentle massage technique that encourages lymph flow
• Should be carefully applied to sensitive lipedema-affected areas

3. Exercise and Physical Activity

• Swimming, aqua therapy, and low-impact walking
• Improves circulation and oxygenation of tissues
• Low-pain, low-impact exercises are ideal

4. Nutritional Counseling

• Focus on anti-inflammatory diet
• Restrict sugar, salt, and processed carbohydrates
• If lymphedema is present, sodium restriction becomes essential

5. Device-Based Therapy

• Non-invasive tools such as pressotherapy, vacuum therapy, laser, and radiofrequency
• Used to reduce fibrosis and enhance lymphatic flow

6. Liposuction (For Advanced Cases)

• If conservative methods fail, lymph-sparing liposuction may be considered
• This is a surgical procedure and should only be performed in experienced centers

What Happens If Lipedema Is Left Untreated?

• Increased pain and restricted movement
• Greater risk of developing lymphedema
• Joint issues, including knee and hip pain
• Psychological effects: depression, social isolation
• Permanent deformities and hardened skin

Lipedema is a progressive condition. Without proper treatment, it can cause irreversible damage and a significant decline in quality of life.

Frequently Asked Questions

Is lipedema caused by being overweight?

No. Lipedema is a disorder of fat distribution. It can occur in people of all body types, including those who are thin.

If I lose weight, will lipedema go away?

No. General body fat may decrease, but the affected areas often remain unchanged. Targeted treatment is necessary.

Is surgery necessary?

No. Surgery is not needed in early stages. It is only considered in advanced cases that do not respond to conservative therapies.

Does lipedema only affect women?

Yes, almost exclusively. It is extremely rare in men and is usually associated with genetic mutations.

Why Choose Us?

• ✅ Specialists in lipedema care: Experienced physicians and physiotherapists
• ✅ Comprehensive evaluation and personalized treatment plans
• ✅ Conservative therapies supported by the latest medical technologies
• ✅ Combined aesthetic and medical approach
• ✅ Comfortable, centrally located clinic in Istanbul

Book Your Appointment Now

Get in touch today to relieve lipedema or varicose vein symptoms and achieve healthier, more confident legs. Our expert team is ready to create your personalized treatment plan.

📞 Phone: 0532 492 85 49
📧 Email: info@drzuhaldurmaz.com
📍 Address: Abdi İpekçi Cad. Reasurans Han 1, Floor 7, Nişantaşı / Istanbul